Perspectives on Gene Regulatory Network Evolution

Perspectives on Gene Regulatory Network Evolution

Animal development proceeds through the activity of genes and their cis -regulatory modules (CRMs) working together in sets of gene regulatory networks (GRNs). The emergence of species-specific traits and novel structures results from evolutionary changes in GRNs. Recent work in a wide variety of an...

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Bibliographic Details
Published in:Trends in genetics Vol. 33; no. 7; pp. 436 - 447
Main Author: Halfon, Marc S
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-07-2017
Subjects:
Animals
cis-regulatory module
developmental system drift
DSD
enhancer evolution
evodevo
Gene Regulatory Networks
Genome
GRN
Insecta - genetics
Medical Education
Phenotype
GRN
cis-regulatory module
enhancer evolution
developmental system drift
evodevo
DSD
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Summary:Animal development proceeds through the activity of genes and their cis -regulatory modules (CRMs) working together in sets of gene regulatory networks (GRNs). The emergence of species-specific traits and novel structures results from evolutionary changes in GRNs. Recent work in a wide variety of animal models, and particularly in insects, has started to reveal the modes and mechanisms of GRN evolution. I discuss here various aspects of GRN evolution and argue that developmental system drift (DSD), in which conserved phenotype is nevertheless a result of changed genetic interactions, should regularly be viewed from the perspective of GRN evolution. Advances in methods to discover related CRMs in diverse insect species, a critical requirement for detailed GRN characterization, are also described.
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ISSN:0168-9525
DOI:10.1016/j.tig.2017.04.005