Drugs for the Prevention and Treatment of Sepsis in the Newborn

Antimicrobial medications are the most commonly used medications in the neonatal intensive care unit. Antibiotics are used for infection prophylaxis, empiric treatment, and definitive treatment of confirmed infection. The choice of medication should be informed by the epidemiology and microbiology o...

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Bibliographic Details
Published in:	Clinics in perinatology Vol. 46; no. 2; pp. 327 - 347
Main Authors:	Mukhopadhyay, Sagori, MD, MMSc, Wade, Kelly C., MD, PhD, MSCE, Puopolo, Karen M., MD, PhD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2019
Subjects:	Anti-Bacterial Agents - therapeutic use Antibiotics Drug Resistance, Microbial Female General Nursing Humans Infant, Newborn Neonatal Sepsis - drug therapy Neonatal Sepsis - prevention & control Newborn Perinatal Care Pregnancy Prophylaxis Sepsis Sepsis Newborn Antibiotics Prophylaxis
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Summary:	Antimicrobial medications are the most commonly used medications in the neonatal intensive care unit. Antibiotics are used for infection prophylaxis, empiric treatment, and definitive treatment of confirmed infection. The choice of medication should be informed by the epidemiology and microbiology of infection in specific clinical scenarios and by the clinical condition of the infant. Understanding evolving pathogen susceptibility to antimicrobials and key pharmacotherapy determinants in neonates can inform optimal antibiotic use.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 All three authors have the same address CHOP Newborn Care, Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107 AUTHOR CONTACT INFORMATION
ISSN:	0095-5108 1557-9840 1557-9840
DOI:	10.1016/j.clp.2019.02.012