Molecular chaperones and the stress of oncogenesis

• Published in: Oncogene Vol. 23; no. 16; pp. 2907 - 2918
• Main Authors: Mosser, Dick D, Morimoto, Richard I
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 12-04-2004
• Subjects: Animals; Apoptosis; Cell death; Cell division; Cell growth; Cell proliferation; Chaperones; Heat; Heat shock proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins - physiology; HSP90 Heat-Shock Proteins - physiology; Humans; Hyperthermia; Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases - metabolism; Mitogen-Activated Protein Kinases - metabolism; Molecular biology; Molecular Chaperones - physiology; Mutation; Neoplasm Proteins - physiology; Neoplasms - etiology; Neoplasms - pathology; Neoplasms - therapy; Protein Folding; Protein structure; Protein synthesis; Shock; Signal Transduction; Tumorigenesis
• ISSN: 0950-9232; 1476-5594
• DOI: 10.1038/sj.onc.1207529

Protein-damaging stresses induce the expression of 'heat-shock proteins', which have essential roles in protecting cells from the potentially lethal effects of stress and proteotoxicity. These stress-protective heat-shock proteins are often overexpressed in cells of various cancers and have been suggested to be contributing factors in tumorigenesis. An underlying basis of oncogenesis is the acquisition and accumulation of mutations that provide the transformed cell with the combined characteristics of deregulated cell proliferation and suppressed cell death. Heat-shock proteins with dual roles as regulators of protein conformation and stress sensors may therefore have intriguing and central roles in both cell proliferation and apoptosis. It has been established that heat-shock proteins exhibit specificity to particular classes of polypeptide substrates and client proteins in vivo, and that chaperones can stabilize mutations that affect the folded conformation. Likewise, overexpression of chaperones has also been shown to protect cells against apoptotic cell death. The involvement of chaperones, therefore, in such diverse roles might suggest novel anticancer therapeutic approaches targeting heat-shock protein function for a broad spectrum of tumor types.