Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 16; p. 2099
• Main Authors: Nguyen, Khoa D, Amerio, Andrea, Aguglia, Andrea, Magnani, Luca, Parise, Alberto, Conio, Benedetta, Serafini, Gianluca, Amore, Mario, Costanza, Alessandra
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-08-2023; MDPI
• Subjects: Alzheimer's disease; Brain; Cardiovascular disease; clinical correlates; Complications and side effects; Development and progression; Genetic analysis; Genetic Association Studies; Health aspects; Health risk assessment; Humans; Hypotheses; Illnesses; Immune system; Immunologic diseases; immunological dysfunction; Immunology; Leukocytes; Lymphocytes; Mental disorders; Microglia; neuroinflammation; Pathogenesis; Review; Risk factors; Schizophrenia; Italy; immunological dysfunction; clinical correlates; schizophrenia; neuroinflammation; microglia
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12162099

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.