The therapeutic applications of antimicrobial peptides (AMPs): a patent review

• Published in: The journal of microbiology Vol. 55; no. 1; pp. 1 - 12
• Main Authors: Kang, Hee-Kyoung, Kim, Cheolmin, Seo, Chang Ho, Park, Yoonkyung
• Format: Journal Article Book Review
• Language: English
• Published: Seoul The Microbiological Society of Korea 01-01-2017; Springer Nature B.V; 한국미생물학회
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antimicrobial Cationic Peptides - chemical synthesis; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - metabolism; Antimicrobial Cationic Peptides - pharmacology; Antimicrobial Cationic Peptides - therapeutic use; Bacteria - drug effects; Biomedical and Life Sciences; Fungi - drug effects; Humans; Life Sciences; Microbiology; Microorganisms; Minireview; Patents as Topic; Peptides; Viruses - drug effects; Yeasts; 생물학; pathogenic bacteria; therapies; antimicrobial peptide; drug candidate
• ISSN: 1225-8873; 1976-3794
• DOI: 10.1007/s12275-017-6452-1

Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.