A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis

• Published in: Trends in biotechnology (Regular ed.) Vol. 17; no. 9; pp. 347 - 351
• Main Authors: Davies, Peter F, Polacek, Denise C, Handen, Jeffrey S, Helmke, Brian P, DePaola, Natacha
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-09-1999; Elsevier Science
• Subjects: Animals; Arteriosclerosis - etiology; Arteriosclerosis - genetics; Arteriosclerosis - pathology; Arteriosclerosis - physiopathology; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cell Separation; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Endothelium, Vascular - physiopathology; Fundamental and applied biological sciences. Psychology; Gene Expression; Genes. Genome; Haemodynamics; Hemodynamics; Humans; Medical sciences; Molecular and cellular biology; Molecular genetics; Regional Blood Flow; RNA, Antisense - genetics; Space life sciences; Transcription, Genetic - genetics; Transcriptional profiles; Turbulent flow; Biotechnology; Turbulent flow; Atherosclerosis; Transcriptional profiles; Genetics; Haemodynamics; Endothelium; Focal lesion; Endothelial cell; Regulation(control); Gene; Induction; Shear stress; Review; Hemodynamics; Gene expression
• ISSN: 0167-7799; 1879-3096
• DOI: 10.1016/S0167-7799(99)01348-7

The initiation and progression of focal atherosclerotic lesions has long been known to be associated with regions of disturbed blood flow. Improved precision in experimental models of spatially defined flow has recently been combined with regional and single-cell gene-expression profiling to investigate the relationships linking haemodynamics to vessel-wall pathobiology.