Evaluation of 8-hydroxy-2-deoxyguanosine and NFkB activation, oxidative stress response, acetylcholinesterase activity, and histopathological changes in rainbow trout brain exposed to linuron

• Published in: Environmental toxicology and pharmacology Vol. 49; pp. 14 - 20
• Main Authors: Topal, Ahmet, Alak, Gonca, Altun, Serdar, Erol, Hüseyin Serkan, Atamanalp, Muhammed
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-01-2017; Elsevier Science Ltd
• Subjects: 8-hydroxy-2-deoxyguanosine; Acetylcholinesterase; Acetylcholinesterase - metabolism; AChE; Animals; Antioxidants; Aquatic life; Aquatic organisms; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain damage; Brain injury; Catalase; Catalase - metabolism; Cholinesterase Inhibitors - toxicity; Damage detection; Deoxyguanosine; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Emergency; Enzymatic activity; Enzyme activity; Exposure; Fish; Fish Proteins - metabolism; Glutathione; Glutathione - metabolism; Herbicides; Herbicides - toxicity; Histopathology; Linuron; Linuron - toxicity; Lipid peroxidation; Lipid Peroxidation - drug effects; NF-kappa B - metabolism; NF-κB protein; NFkB; Oncorhynchus mykiss; Oncorhynchus mykiss - metabolism; Oxidative stress; Oxidative Stress - drug effects; Peroxidation; Pesticide; Plant tissues; Superoxide dismutase; Superoxide Dismutase - metabolism; Toxicity; Trout; toxicity; AChE; Pesticide; fish; 8-hydroxy-2-deoxyguanosine; histopathology; NFkB; oxidative stress; linuron; Oxidative stress; Histopathology; Toxicity; Linuron; Fish
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2016.11.009

Highlights • We evaluated biochemical and physiological effects in the brain tissues of rainbow trout exposed to linuron. • 8-OHdG and NFkB immunopositivity was detected in brain tissues exposed to linuron. • Linuron exposure causes oxidative and histopathological damage in brain tissues. • Linuron may disturb the biochemical and physiological functions of fish.