Bacteria-Targeted Clindamycin Loaded Polymeric Nanoparticles: Effect of Surface Charge on Nanoparticle Adhesion to MRSA, Antibacterial Activity, and Wound Healing

Adhesion of nanoparticles (NPs) to the bacterial cell wall by modifying their physicochemical properties can improve the antibacterial activity of antibiotic. In this study, we prepared positively charged clindamycin-loaded poly (lactic-co-glycolic acid)-polyethylenimine (PLGA-PEI) nanoparticles (Cl...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 11; no. 5; p. 236
Main Authors:	Hasan, Nurhasni, Cao, Jiafu, Lee, Juho, Hlaing, Shwe Phyu, Oshi, Murtada A, Naeem, Muhammad, Ki, Min-Hyo, Lee, Bok Luel, Jung, Yunjin, Yoo, Jin-Wook
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 15-05-2019 MDPI
Subjects:	antibacterial Antibiotics Antimicrobial agents Bacteria Bacterial infections clindamycin Drug delivery systems Morphology MRSA-infected wound healing Nanoparticles Particle size Scanning electron microscopy Staphylococcus infections surface charge Wound healing United States > US Germany surface charge MRSA-infected wound healing antibacterial nanoparticles clindamycin
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