A case of cigarette smoking-induced acute eosinophilic pneumonia showing tolerance

It has been proposed that acute eosinophilic pneumonia (AEP), which is characterized by the absence of recurrence, is associated with cigarette smoking (CS), because Japanese patients with AEP are young and have a high incidence of short-term smoking history. However, there has been no direct eviden...

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Bibliographic Details
Published in:	Chest Vol. 117; no. 1; p. 277
Main Authors:	Shintani, H, Fujimura, M, Ishiura, Y, Noto, M
Format:	Journal Article
Language:	English
Published:	United States 01-01-2000
Subjects:	Acute Disease Adult Antigens - immunology Biopsy Bronchoalveolar Lavage Fluid - cytology Diagnosis, Differential Humans Male Nicotiana - immunology Plants, Toxic Pulmonary Eosinophilia - diagnosis Pulmonary Eosinophilia - etiology Pulmonary Eosinophilia - physiopathology Radiography, Thoracic Respiratory Function Tests Smoking - adverse effects Smoking - immunology
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Summary:	It has been proposed that acute eosinophilic pneumonia (AEP), which is characterized by the absence of recurrence, is associated with cigarette smoking (CS), because Japanese patients with AEP are young and have a high incidence of short-term smoking history. However, there has been no direct evidence that CS causes AEP. We hypothesized that tolerance might develop against repeated resumption of smoking cigarettes in CS-induced AEP cases. In this connection, we challenged a patient with CS-induced AEP with repeated resumption of CS, and it was demonstrated that CS induced AEP in conjunction with tolerance to repeated resumption of smoking.
ISSN:	0012-3692
DOI:	10.1378/chest.117.1.277