Sequential SPECT and Optical Imaging of Experimental Models of Prostate Cancer with a Dual Modality Inhibitor of the Prostate-Specific Membrane Antigen

One reagent for two techniques: Compound [111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate‐specific membrane antigen. Because the same subject can be dual‐imaged after one injection of the agent, these findings support r...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 50; no. 39; pp. 9167 - 9170
Main Authors:	Banerjee, Sangeeta Ray, Pullambhatla, Mrudula, Byun, Youngjoo, Nimmagadda, Sridhar, Foss, Catherine A., Green, Gilbert, Fox, James J., Lupold, Shawn E., Mease, Ronnie C., Pomper, Martin G.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 19-09-2011 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Animals Fluorescent Dyes - chemistry fluorescent probes Heterocyclic Compounds, 1-Ring - chemistry imaging agents Indium Radioisotopes - chemistry Male Mice Peptides - chemistry Peptides - pharmacokinetics Porphyrins - chemistry Porphyrins - pharmacokinetics Prostate cancer Prostate-Specific Antigen - antagonists & inhibitors Prostate-Specific Antigen - metabolism prostate-specific membrane antigen Prostatic Neoplasms - diagnostic imaging Protease Inhibitors - chemistry Protease Inhibitors - pharmacokinetics radiochemistry Tissue Distribution Tomography, Emission-Computed, Single-Photon Transplantation, Heterologous
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Summary:	One reagent for two techniques: Compound [111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate‐specific membrane antigen. Because the same subject can be dual‐imaged after one injection of the agent, these findings support rapid clinical translation.
Bibliography:	ark:/67375/WNG-FZJMDTKP-4 ArticleID:ANIE201102872 We thank Dr. David Wasserman of LI-COR Biosciences for use of their equipment and guidance in the in vivo study. We also thank U24 CA92871, R01 CA134675 and K25 CA148901 for financial support. SPECT=single photon emission computed tomography. K25 - No. CA148901 istex:A2C41C9F7D66A427B3586281176D9A786CBEFE90 U24 - No. CA92871 R01 - No. CA134675 We thank Dr. David Wasserman of LI‐COR Biosciences for use of their equipment and guidance in the in vivo study. We also thank U24 CA92871, R01 CA134675 and K25 CA148901 for financial support. SPECT=single photon emission computed tomography.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201102872