Motor-related functional subdivisions of human lateral premotor cortex: epicortical recording in conditional visuomotor task

• Published in: Clinical neurophysiology Vol. 114; no. 6; pp. 1102 - 1115
• Main Authors: Matsumoto, Riki, Ikeda, Akio, Ohara, Shinji, Matsuhashi, Masao, Baba, Kouichi, Yamane, Fumitaka, Hori, Tomokatsu, Mihara, Tadahiro, Nagamine, Takashi, Shibasaki, Hiroshi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-06-2003; Elsevier Science
• Subjects: Adolescent; Adult; Biological and medical sciences; Brain Mapping; Choice Behavior; Conditional visuomotor paradigm; Electroencephalography; Epicortical recording; Epilepsy - physiopathology; Event-related potential; Evoked Potentials, Visual - physiology; Female; Functional subdivision; Fundamental and applied biological sciences. Psychology; Go/NoGo; Humans; Lateral premotor cortex; Male; Middle Aged; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Motor Cortex - anatomy & histology; Motor Cortex - physiopathology; Movement; Neuropsychological Tests; Psychomotor Performance; Reaction Time; Set (Psychology); Vertebrates: nervous system and sense organs; Event-related potential; Lateral premotor cortex; Conditional visuomotor paradigm; Epicortical recording; Functional subdivision; Go/NoGo; Human; Motor pathway; Central nervous system; Electrophysiology; Cognition; Motor control; Choice reaction time; Perception; Premotor cortex; Event evoked potential; Visuomotor control; Motor preparation
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/S1388-2457(03)00065-8

Objective: To clarify the functional subdivisions of the human lateral premotor cortex (PM) in the visuomotor control.
Methods: Event-related potentials (ERPs) were epicortically recorded from PM in 5 epilepsy patients. S1-Go/NoGo choice delayed reaction time (RT), S1-warned S2-Go simple RT and control fixation paradigms were compared using paired visual stimuli (S1, S2).
Results: Signal-related activity peaked at 176–194 ms after S1 in the ventrorostral PM (PMvr) in all 3 paradigms, indicating its role in signal perception. Early set-related activity was recorded with its peak <810 ms after S1 in the dorsorostral PM (PMdr) and was larger in the choice than in the simple RT paradigm, suggesting its role in signal selection. Its cognitive component was recorded as surface-positive transients at PMdr, while its motoric aspect, seen as negative transients, extended to the caudal PM. Late sustained set-related activity was observed in preparation for hand movement in the caudal PM at the hand and face positive motor areas. After presentation of S2, movement-related activity was observed at the hand sensorimotor area for motor execution, following the signal-related activity at PMvr.
Conclusions: The present ERP study suggests the temporally sequential representation of predominantly ‘cognitive’ function in the rostral PM and ‘motor’ function in the caudal PM.
Significance: The rostrocaudal cognitive-motor gradient was demonstrated in the lateral premotor cortex in humans by means of an epicortical ERP approach.