Vasoactive Intestinal Peptide-Receptor Imaging for the Localization of Intestinal Adenocarcinomas and Endocrine Tumors

• Published in: The New England journal of medicine Vol. 331; no. 17; pp. 1116 - 1121
• Main Authors: Virgolini, Irene, Raderer, Markus, Kurtaran, Amir, Angelberger, Peter, Banyai, Martin, Banyai, Susanne, Yang, Qiong, Li, Shuren, Pidlich, Johann, Niederle, Bruno, Scheithauer, Werner, Valent, Peter
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 27-10-1994
• Subjects: Abdomen; Adenocarcinoma - diagnostic imaging; Adenocarcinoma - metabolism; Cameras; Carcinoid Tumor - diagnostic imaging; Carcinoid Tumor - metabolism; Chromatography; Colorectal carcinoma; Colorectal Neoplasms - diagnostic imaging; Colorectal Neoplasms - metabolism; Computed tomography; Digestive system; Female; Gastric cancer; Gastrointestinal Neoplasms - diagnostic imaging; Gastrointestinal Neoplasms - metabolism; High-performance liquid chromatography; Humans; Injection; Insulinoma; Insulinoma - diagnostic imaging; Insulinoma - metabolism; Internal medicine; Intestine; Intravenous administration; Iodine; Iodine Radioisotopes; Liver; Localization; Lungs; Lymph nodes; Male; Medical imaging; Medical research; Metastases; Metastasis; Neuroendocrine tumors; Nuclear medicine; Octreotide; Pancreatic cancer; Pancreatic carcinoma; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - metabolism; Peptides; Radionuclide Imaging; Receptors, Somatostatin - analysis; Receptors, Vasoactive Intestinal Peptide - analysis; Scanning; Somatostatin; Stomach Neoplasms - diagnostic imaging; Stomach Neoplasms - metabolism; Surgery; Thorax; Tumors; Vasoactive agents; Vasoactive Intestinal Peptide; Visualization
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199410273311703

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuroendocrine mediator with a broad range of activities in diverse cells and tissues. The peptide is a major regulator of water and electrolyte secretion in the gut
1
and causes the watery-diarrhea syndrome in patients with VIP-secreting tumors
2
,
3
. VIP also regulates various immune cells
4
,
5
and the growth and function of tumor cells
6
. Receptors for VIP have been detected on the cell-surface membrane of intestinal epithelial cells,
7
,
8
lung tissue,
9
and lymphohemopoietic cells
6
. Various tumor cells, including colonic adenocarcinomas,
6
,
8
,
10
,
11
pancreatic carcinomas,
12
and carcinoids,
6
express large numbers of . . .