Aging Alteration of Cardiac Vagosympathetic Balance Assessed Through the Tone-Entropy Analysis

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 54; no. 5; pp. M219 - M224
• Main Authors: Oida, Eiichi, Kannagi, Toshiko, Moritani, Toshio, Yamori, Yukio
• Format: Journal Article
• Language: English
• Published: United States The Gerontological Society of America 01-05-1999; Oxford University Press
• Subjects: Adrenergic beta-Antagonists - pharmacology; Adult; Aged; Aging; Aging - physiology; Atropine - pharmacology; Autonomic Nervous System - physiology; Cardiology; Efferent Pathways - physiology; Electrocardiography; Entropy; Exercise - physiology; Gerontology; Heart - physiology; Heart Conduction System - drug effects; Heart Conduction System - physiology; Heart Rate - drug effects; Heart Rate - physiology; Humans; Male; Middle Aged; Neurons, Efferent - physiology; Parasympatholytics - pharmacology; Propranolol - pharmacology; Supine Position; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - physiology; Sympatholytics - pharmacology; Vagus Nerve - drug effects; Vagus Nerve - physiology
• ISSN: 1079-5006; 1758-535X
• DOI: 10.1093/gerona/54.5.M219

Background. Age-associated alterations of cardiac autonomic functions have been investigated intensively through heart rate variability analyses. However, changes with age in cardiac vagosympathetic balance remain to be elucidated. Methods. We studied 142 male subjects (30–69 yr) at a health care center in Kyoto, Japan. Electrocardiographic data were collected from subjects in a recumbent position for 10 min in the morning. Analysis was done by classifying the subjects into four age groups. In a pharmacological experiment carried out in December 1996, tone was verified to reflect the cardiac vagosympathetic balance, and entropy the total autonomic neural efferent activity. We assessed the heart rate variability through the tone-entropy (T-E) analysis that was described previously. In essence, two indexes, tone and entropy, were defined on a distribution of successive variations of heart period. Results. No significant differences were detected in clinical conditions among the four age groups. Tone increased and entropy decreased significantly with age. The aging process was expressed as a curvilinear path in T-E space. Compared to the pharmacological experiment, it was observed that aging degenerated the heart function from an ordinary to a denervated one. The same aging path was superimposed in the opposite direction on the heart recovery path after dynamic exercise in which cardiac vagosympathetic balance tended toward vagus division, corresponding with restoration of total autonomic activity. Conclusions. An age-related reduction in cardiac autonomic function was consistent with previous reports. The vagosympathetic balance was altered with this reduction: vagal predominance was impaired significantly in proportion to the withdrawal of total cardiac autonomic activity.