The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

• Published in: Journal of neuroimmunology Vol. 285; pp. 143 - 146
• Main Authors: Moreira, Fernanda Pedrotti, Cardoso, Taiane de Azevedo, Mondin, Thaíse Campos, Souza, Luciano Dias de Mattos, Silva, Ricardo, Jansen, Karen, Oses, Jean Pierre, Wiener, Carolina David
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-08-2015
• Subjects: Adolescent; Adult; Allergy and Immunology; Biomarkers - blood; Cognitive Behavioral Therapy (CBT); Cognitive Therapy - trends; Cytokines - blood; Cytokines - immunology; Depression; Depressive Disorder, Major - blood; Depressive Disorder, Major - immunology; Depressive Disorder, Major - therapy; Double-Blind Method; Female; Humans; Inflammation Mediators - blood; Inflammation Mediators - immunology; Interleukin-6 (IL-6); Male; Neurology; Proinflammatory cytokines; Tumor necrosis factor alpha (TNF-α); Young Adult; Depression; Tumor necrosis factor alpha (TNF-α); Interleukin-6 (IL-6); Proinflammatory cytokines; Cognitive Behavioral Therapy (CBT)
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2015.06.004

Abstract Major depressive disorder (MDD) is a debilitating disorder and its pathophysiology is associated with deregulation of the immune system. We investigated the changes in circulating levels of proinflammatory cytokines (specifically IL-6 and TNF-α) measured by the ELISA kit in two psychotherapeutic interventions for MDD: Narrative Cognitive Therapy (NCT) and Cognitive Behavioral Therapy (CBT). This is a randomized clinical trial including 97 individuals (18 to 29 years-old) with MDD. In CBT there was a significant difference in serum levels of IL-6 and TNF-α, therefore indicating that CBT was more effective than NCT on serum levels proinflammatory cytokines.