Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts

• Published in: Bioorganic & medicinal chemistry Vol. 19; no. 13; pp. 4051 - 4056
• Main Authors: Morita, Hiroshi, Zaima, Kazumasa, Koga, Ikumi, Saito, Aiko, Tamamoto, Haruka, Okazaki, Hiroki, Kaneda, Toshio, Hashimoto, Toshihiro, Asakawa, Yoshinori
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-07-2011; Elsevier
• Subjects: Animals; aorta; Aorta - cytology; Bibenzyls - chemistry; Biological and medical sciences; Bis(bibenzyls); calcium; Calcium Channels - chemistry; Calcium Channels - metabolism; Cells, Cultured; endothelial cells; Endothelial Cells - drug effects; General pharmacology; Hepatophyta - chemistry; Liverwort; Macrocyclic Compounds - chemistry; Macrocyclic Compounds - isolation & purification; Macrocyclic Compounds - pharmacology; Male; Marchantia paleacea; Marchantia polymorpha; Medical sciences; mosses and liverworts; nitric oxide; Nitric Oxide - metabolism; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phenylephrine; potassium channels; Rats; Rats, Wistar; ROC; Structure-Activity Relationship; structure-activity relationships; vasodilation; Vasodilator Agents - chemistry; Vasodilator Agents - isolation & purification; Vasodilator Agents - pharmacology; Vasorelaxant effects; VDC; NO; Bis(bibenzyls); Liverwort; VDC; Vasorelaxant effects; ROC; Vasodilator agent; Rat; Hepaticae; Macrocycle; Receptor operated channel; Structure activity relation; Aorta; Cyclophane; Mechanism of action; Voltage-gated canal; Pharmacognosy; Rodentia; Bryophyta; In vitro; Vertebrata; Mammalia; Animal; Nitric oxide; Plant origin; Phenols
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2011.05.019

Vasorelaxant effects of a series of bis(bibenzyls) from liverworts such as
Marchantia polymorpha and
Marchantia paleacea on rat aorta demonstrated that they relaxed phenylephrine (PE)-induced contractions, which may be mediated through the increased release of NO from endothelial cells as well as opening of K
+ channels, and inhibition of Ca
2+ influx through voltage-dependent Ca
2+ channels (VDCs) and/or receptor-operated Ca
2+ channels (ROCs). Structure–activity relationship based on their structures was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer may play an important role for vasorelaxant effect.