Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens
Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We c...
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| Published in: | Scientific reports Vol. 7; no. 1; p. 43741 |
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| Main Authors: | , , , , , , , |
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06-03-2017
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| Abstract | Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing. These individuals were on two ART regimens based on either Non-Nucleoside Reverse Transcriptase Inhibitors (EFV) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcriptase Inhibitors. Microbiome diversity was reduced in treated HIV infection compared to HIV SN (p < 0.05). Several operational taxonomic units (OTUs) related to the Ruminococcaceae family including
Faecalibacterium prausnitzii
were depleted in EFV and PI compared to HIV SN and negatively correlated with intestinal gut dysfunction as measured by the intestinal fatty binding protein (p < 0.05). This is the first report to address the fecal bacterial communities in HIV-infected individuals on two ARV regimens from Mexico. |
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| AbstractList | Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing. These individuals were on two ART regimens based on either Non-Nucleoside Reverse Transcriptase Inhibitors (EFV) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcriptase Inhibitors. Microbiome diversity was reduced in treated HIV infection compared to HIV SN (p < 0.05). Several operational taxonomic units (OTUs) related to the Ruminococcaceae family including Faecalibacterium prausnitzii were depleted in EFV and PI compared to HIV SN and negatively correlated with intestinal gut dysfunction as measured by the intestinal fatty binding protein (p < 0.05). This is the first report to address the fecal bacterial communities in HIV-infected individuals on two ARV regimens from Mexico. Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing. These individuals were on two ART regimens based on either Non-Nucleoside Reverse Transcriptase Inhibitors (EFV) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcriptase Inhibitors. Microbiome diversity was reduced in treated HIV infection compared to HIV SN (p < 0.05). Several operational taxonomic units (OTUs) related to the Ruminococcaceae family including Faecalibacterium prausnitzii were depleted in EFV and PI compared to HIV SN and negatively correlated with intestinal gut dysfunction as measured by the intestinal fatty binding protein (p < 0.05). This is the first report to address the fecal bacterial communities in HIV-infected individuals on two ARV regimens from Mexico. Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing. These individuals were on two ART regimens based on either Non-Nucleoside Reverse Transcriptase Inhibitors (EFV) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcriptase Inhibitors. Microbiome diversity was reduced in treated HIV infection compared to HIV SN (p < 0.05). Several operational taxonomic units (OTUs) related to the Ruminococcaceae family including Faecalibacterium prausnitzii were depleted in EFV and PI compared to HIV SN and negatively correlated with intestinal gut dysfunction as measured by the intestinal fatty binding protein (p < 0.05). This is the first report to address the fecal bacterial communities in HIV-infected individuals on two ARV regimens from Mexico. |
| ArticleNumber | 43741 |
| Author | Briceño, Olivia Téllez, Norma Reyes-Terán, Gustavo Alva-Hernández, Selma Pinto-Cardoso, Sandra Murakami-Ogasawara, Akio Lozupone, Catherine Adriana, Aguilar |
| Author_xml | – sequence: 1 givenname: Sandra surname: Pinto-Cardoso fullname: Pinto-Cardoso, Sandra organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases – sequence: 2 givenname: Catherine surname: Lozupone fullname: Lozupone, Catherine organization: Department of Medicine, University of Colorado – sequence: 3 givenname: Olivia surname: Briceño fullname: Briceño, Olivia organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases – sequence: 4 givenname: Selma surname: Alva-Hernández fullname: Alva-Hernández, Selma organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases – sequence: 5 givenname: Norma surname: Téllez fullname: Téllez, Norma organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases – sequence: 6 givenname: Aguilar surname: Adriana fullname: Adriana, Aguilar organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases – sequence: 7 givenname: Akio surname: Murakami-Ogasawara fullname: Murakami-Ogasawara, Akio organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases – sequence: 8 givenname: Gustavo surname: Reyes-Terán fullname: Reyes-Terán, Gustavo email: gustavo.reyesteran@gmail.com organization: Center for Research in Infectious Diseases, National Institute of Respiratory Diseases |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28262770$$D View this record in MEDLINE/PubMed |
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21 IH McHardy (BFsrep43741_CR13) 2013; 1 AE Dikman (BFsrep43741_CR25) 2015; 60 BFsrep43741_CR44 RD Macarthur (BFsrep43741_CR24) 2013; 19 NG Sandler (BFsrep43741_CR32) 2011; 203 P Nowak (BFsrep43741_CR12) 2015; 29 DV Havlir (BFsrep43741_CR4) 2015; 23 ML Zupancic (BFsrep43741_CR35) 2012; 7 A Gorvitovskaia (BFsrep43741_CR28) 2016; 4 SM Dillon (BFsrep43741_CR17) 2014; 7 BFsrep43741_CR27 LR Lopetuso (BFsrep43741_CR36) 2013; 5 Q Wang (BFsrep43741_CR46) 2007; 73 MJ Siedner (BFsrep43741_CR2) 2016; 3 D Saylor (BFsrep43741_CR3) 2016; 12 C Lozupone (BFsrep43741_CR30) 2005; 71 H Zhang (BFsrep43741_CR34) 2009; 106 DP Faith (BFsrep43741_CR47) 2006; 2 NR Klatt (BFsrep43741_CR6) 2013; 254 GD Wu (BFsrep43741_CR21) 2011; 334 RC Edgar (BFsrep43741_CR45) 2010; 26 T Yatsunenko (BFsrep43741_CR22) 2012; 486 EA Mutlu (BFsrep43741_CR10) 2014; 10 DM Dinh (BFsrep43741_CR14) 2015; 211 A Klindworth (BFsrep43741_CR43) 2013; 41 ME Mejia-Leon (BFsrep43741_CR29) 2014; 4 C De Filippo (BFsrep43741_CR23) 2010; 107 MM Lederman (BFsrep43741_CR8) 2013; 119 G Block (BFsrep43741_CR42) 2006; 3 R Landmann (BFsrep43741_CR31) 1996; 64 RF Benus (BFsrep43741_CR39) 2010; 104 SG Deeks (BFsrep43741_CR1) 2013; 39 H Sokol (BFsrep43741_CR38) 2008; 105 I Vujkovic-Cvijin (BFsrep43741_CR11) 2013; 5 BFsrep43741_CR18 BFsrep43741_CR19 M Hernandez-Avila (BFsrep43741_CR41) 1998; 40 V Montessori (BFsrep43741_CR26) 2004; 170 J Perez-Santiago (BFsrep43741_CR15) 2013; 27 C Manichanh (BFsrep43741_CR37) 2006; 55 K Machiels (BFsrep43741_CR40) 2014; 63 M Noguera-Julian (BFsrep43741_CR16) 2016; 5 CE West (BFsrep43741_CR5) 2015; 135 CA Lozupone (BFsrep43741_CR9) 2013; 14 M Arumugam (BFsrep43741_CR20) 2011; 473 H Funaoka (BFsrep43741_CR33) 2010; 58 |
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| Title | Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens |
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