Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes

• Published in: Journal of ethnopharmacology Vol. 127; no. 2; pp. 555 - 557
• Main Authors: Somasundaram, Arumugam, Karthikeyan, Ramadoss, Velmurugan, Vadivel, Dhandapani, Balasubramanian, Raja, Muthu
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 03-02-2010; Amsterdam; New York: Elsevier; Elsevier
• Subjects: animal models; Animals; Biological and medical sciences; Carbon Tetrachloride - toxicity; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - prevention & control; Cyperaceae; dosage; dose response; General pharmacology; Hepatoprotective; hepatoprotective effect; Hepatotoxicity; histopathology; Kyllinga; Kyllinga nemoralis; liver function; Medical sciences; medicinal plants; medicinal properties; oral administration; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Rhizome; rhizomes; Kyllinga nemoralis; Hepatoprotective; Hepatotoxicity; Rhizome; Evaluation; Digestive system; Hepatoprotector; Pharmacognosy; Toxicity; Liver; Medicinal plant; Plant origin; Below ground plant part
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2009.11.014

In view of the use of rhizomes of
Kyllinga nemoralis L., against hepatopathy in ethnomedicine the present study was aimed at evaluating the hepatoprotective activity of the rhizomes of
Kyllinga nemoralis against carbon tetrachloride (CCl
4)-induced hepatotoxicity in rats.
Hepatotoxicity was induced in male Wistar rats by carbon tetrachloride and olive oil (50%, v/v). i.p. ethanolic and petroleum ether extracts of
Kyllinga nemoralis rhizomes were administered to the experimental rats (100 and 200
mg/kg, p.o. for seven days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters and histopathological studies of the liver compared with silymarin.
Both extracts showed significant hepatoprotection when compared to control, similar to standard silymarin. Histology of liver sections also revealed that the extracts protected liver from injury.
The study identified a plant with potential hepatoprotective constituents which will be isolated and characterized in future.