SMART: a web-based tool for the study of genetically mobile domains

• Published in: Nucleic acids research Vol. 28; no. 1; pp. 231 - 234
• Main Authors: Schultz, J, Copley, R R, Doerks, T, Ponting, C P, Bork, P
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01-01-2000; Oxford University Press
• Subjects: Database Management Systems; Information Storage and Retrieval; Internet; Proteins - chemistry; Sequence Alignment; Simple Modular Architecture Research Tool
• ISSN: 0305-1048; 1362-4962; 1362-4962
• DOI: 10.1093/nar/28.1.231

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.