Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV

• Published in: Vaccine Vol. 30; no. 3; pp. 607 - 613
• Main Authors: Ali Tabei, S.M, Li, Ying, Weigert, Martin, Dinner, Aaron R
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 11-01-2012; Elsevier Limited
• Subjects: Allergy and Immunology; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antiretroviral drugs; Behavior; Broadly neutralizing antibodies; Competition; Cytotoxicity; HIV; HIV Antibodies - administration & dosage; HIV Antibodies - immunology; HIV Infections - therapy; Human immunodeficiency virus; Humans; humoral immunity; Hypotheses; Immunization; Immunization, Passive - methods; Infections; Influenza; Lymphocytes; Mathematical model; Mathematical models; Models, Theoretical; neutralizing antibodies; Passive immunization; Self epitopes; vaccines; Viral infections; Viral Load; Viruses; Self epitopes; HIV; Mathematical model; Passive immunization; Broadly neutralizing antibodies
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.11.048

Highlights ► We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo . ► We use the model to fit patient data. ► The model enables us to identify a threshold antibody level that must be achieved to decrease the viral load effectively. ► In an appendix, we develop a model of passive immunization against influenza, and acute infection.