Effects of Placental Secretory Factors on Cytokine Production by Endothelial Cells

• Published in: Bulletin of experimental biology and medicine Vol. 154; no. 3; pp. 375 - 378
• Main Authors: Stepanova, O. I., Safronova, N. U., Furaeva, K. N., Lvova, T. U., Sokolov, D. I., Selkov, S. A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 2013; Springer; Springer Nature B.V
• Subjects: Angiogenin; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Line; Chemokine CCL2 - metabolism; Chemokine CCL5 - metabolism; Cytokines; Cytokines - metabolism; Endothelial Cells - metabolism; Endothelium; Experimental Methods for Clinical Practice; Female; Fibroblast Growth Factor 2 - metabolism; Fibroblast growth factors; Humans; Inflammation; Interleukin-8 - metabolism; Internal Medicine; Laboratory Medicine; Pathology; Placenta - cytology; Placenta - metabolism; Pre-Eclampsia - metabolism; Pregnancy; Ribonuclease, Pancreatic - metabolism; Trophoblasts - metabolism; placenta; endothelial cells; cytokines
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-1954-2

We studied the effects of soluble products of the placental tissue from women with normal pregnancy and gestosis on the cytokine secretion by endothelial EA.Hy926 cells. The secretory products of the placental tissue induced the production of angiogenin, bFGF, IL-8, MCP-1, and RANTES by endothelial cells. The secretion of bFGF by EA.Hy926 cells increased, while IL-8 secretion decreased under the effects of factors produced by the placental tissue in gestosis but not in normal pregnancy. This could be aimed at reduction of inflammation intensity in the placental tissue and maintenance of endothelial and trophoblast cells viability.