Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer

• Published in: International journal of molecular sciences Vol. 25; no. 1; p. 115
• Main Authors: Das, Chandrima, Martín, Cristina, Habermann, Sebastian, Walker, Harriet Rose, Iqbal, Javed, Elies, Jacobo, Jones, Huw Simon, Reina, Giacomo, Ruiz, Amalia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21-12-2023; MDPI
• Subjects: Ablation; Antimitotic agents; Antineoplastic agents; black phosphorus nanoflakes; Cancer; Cancer therapies; Chemotherapy; Combination therapy; Fever; Health aspects; Hyperthermia; Immunotherapy; Light; Lipids; LTSL; Nanomaterials; Nanoparticles; Phosphorus; Photochemotherapy; photodynamic therapy; phototherapy; Prostate cancer; Quantum dots; Tumors; Iran; United Kingdom; Germany; black phosphorus nanoflakes; LTSL; phototherapy; photodynamic therapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25010115

Black phosphorus (BP) is one of the most promising nanomaterials for cancer therapy. This 2D material is biocompatible and has strong photocatalytic activity, making it a powerful photosensitiser for combined NIR photothermal and photodynamic therapies. However, the fast degradation of BP in oxic conditions (including biological environments) still limits its use in cancer therapy. This work proposes a facile strategy to produce stable and highly concentrated BP suspensions using lysolipid temperature-sensitive liposomes (LTSLs). This approach also allows for co-encapsulating BP nanoflakes and doxorubicin, a potent chemotherapeutic drug. Finally, we demonstrate that our BP/doxorubicin formulation shows per se high antiproliferative action against an in vitro prostate cancer model and that the anticancer activity can be enhanced through NIR irradiance.