Interleukin-1 Gene Polymorphisms in Chronic Gastritis Patients Infected with Helicobacter pylori as Risk Factors of Gastric Cancer Development

• Published in: Archivum Immunologiae et Therapiae Experimentalis Vol. 61; no. 6; pp. 503 - 512
• Main Authors: Hnatyszyn, Andrzej, Wielgus, Karolina, Kaczmarek-Rys, Marta, Skrzypczak-Zielinska, Marzena, Szalata, Marlena, Mikolajczyk-Stecyna, Joanna, Stanczyk, Jerzy, Dziuba, Ireneusz, Mikstacki, Adam, Slomski, Ryszard
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01-12-2013; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biomedical and Life Sciences; Biomedicine; Carcinogenesis - genetics; Carcinoma - immunology; DNA Mutational Analysis; Gastritis - immunology; Gene Frequency; Genetic Association Studies; Genotype; Helicobacter Infections - immunology; Helicobacter pylori; Helicobacter pylori - immunology; Humans; Immunology; Interleukin-1 - genetics; Intestinal Mucosa - pathology; Male; Original; Original Article; Pharmacology/Toxicology; Polymorphism, Genetic; Risk Factors; Stomach Neoplasms - immunology; Young Adult; Interleukin-1; Chronic gastritis; Gastric cancer; Polymorphism
• ISSN: 0004-069X; 1661-4917
• DOI: 10.1007/s00005-013-0245-y

Epidemiological investigations indicated association of the
Helicobacter pylori
infections with the occurrence of inflammatory conditions of the gastric mucosa and development of chronic gastritis and intestinal type of gastric cancer.
IL1A
and
IL1B
genes have been proposed as key factors in determining risk of gastritis and malignant transformation. The aim of this paper was to evaluate association of interleukin-1 gene polymorphisms with chronic gastritis, atrophy, intestinal metaplasia, dysplasia and intestinal type of gastric cancer in
H. pylori-
infected patients. Patients subjected to analysis represent group of 144 consecutive cases that suffered from dyspepsia with coexisting infection of
H. pylori
and chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia or gastric cancer. Molecular studies involved analysis of –889C>T polymorphism of
IL1A
gene and +3954C>T polymorphism of
IL1B
gene. Statistical analysis of association of polymorphism –889C>T of gene
IL1A
with changes in gastric mucosa showed lack of significance, whereas +3954C>T polymorphism of
IL1B
gene showed significant association. Frequency of allele T of +3954C>T polymorphism of
IL1B
gene was higher in group of patients with chronic gastritis, atrophy, intestinal metaplasia, dysplasia or intestinal type of gastric cancer (32.1 %) as compared with population group (23 %), χ
2
 = 4.61 and
p
 = 0.03. This corresponds to odds ratio: 1.58, 95 % CI: 1.04–2.4. Our results indicate that +3954C>T polymorphism of
IL1B
gene increase susceptibility to inflammatory response of gastric mucosa
H. pylori
-infected patients and plays a significant role in the development of chronic gastritis, atrophy, intestinal metaplasia, dysplasia and the initiation of carcinogenesis.