Modification of Collagen Formation by Mesenchymal Stem Cells Isolated from Human Adipose Tissue in Culture and after Autotransplantation for Abdominal Hernia Plasty

• Published in: Bulletin of experimental biology and medicine Vol. 156; no. 1; pp. 152 - 155
• Main Authors: Bogdan, V. G., Zafranskaya, M. M., Gain, Yu. M., Demidchik, Yu. E., Bagatka, S. S., Ivanchik, G. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-11-2013; Springer; Springer Nature B.V
• Subjects: Adipose Tissue, White - pathology; Adipose tissues; Autografts; Biomedical and Life Sciences; Biomedicine; Body fat; Cell Biology; Cells, Cultured; Collagen; Collagen Type I - metabolism; Collagen Type III - metabolism; Combined Modality Therapy; Hernia; Hernia, Abdominal - metabolism; Hernia, Abdominal - therapy; Herniorrhaphy; Humans; Internal Medicine; Laboratory Medicine; Mesenchymal Stem Cell Transplantation; Pathology; collagen; autotransplantation; mesenchymal stem cells; postoperative hernia
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-2299-6

Mesenchymal stem cells from the adipose tissue of patients with postoperative hernias produce excessive amounts of collagen III, which shifts the balance between type III and type I collagens. The proposed technique of pretransplantation preparation allows
in vitro
stimulation collagen formation processes with predominant activation of collagen I synthesis and normalization of proportion between different collagen types. Abdominal wall repair with polypropylene surgical mesh in combination with autotransplantation of mesenchymal stem cells reduced the collagen III to collagen I ratio due to activation of collagen I synthesis and suppression of collagen III production, which had a positive effect on the structure of
in vivo
formed connective tissue.