Non-atopic IgE and eosinophil cationic protein after allogeneic hematopoietic stem cell transplantation in children

• Published in: Annals of hematology Vol. 91; no. 6; pp. 949 - 956
• Main Authors: Fazekas, T., Pruckner, N., Lawitschka, A., Seidel, M. G., Eickhoff, P., Pötschger, U., Szépfalusi, Z., Gadner, H., Peters, C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-06-2012; Springer Nature B.V
• Subjects: Adolescent; Age; Atopy; Child; Child, Preschool; Children; Cryptogenic Organizing Pneumonia - blood; Cryptogenic Organizing Pneumonia - diagnosis; Cryptogenic Organizing Pneumonia - epidemiology; Cryptogenic Organizing Pneumonia - etiology; Eosinophil cationic protein; Eosinophil Cationic Protein - blood; Eosinophilia; Female; Graft vs Host Disease - blood; Graft vs Host Disease - diagnosis; Graft vs Host Disease - epidemiology; Graft vs Host Disease - immunology; Graft-versus-host reaction; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic Stem Cell Transplantation - statistics & numerical data; Humans; Hypersensitivity; Hypersensitivity, Immediate - blood; Hypersensitivity, Immediate - epidemiology; Hypersensitivity, Immediate - immunology; Immunoglobulin E; Immunoglobulin E - blood; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - epidemiology; Leukemia, Myeloid, Acute - therapy; Leukocytes (eosinophilic); Lung; Lung Diseases - blood; Lung Diseases - diagnosis; Lung Diseases - epidemiology; Lung Diseases - etiology; Lung transplantation; Male; Medicine; Medicine & Public Health; Oncology; Original; Original Article; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Prevalence; stem cell transplantation; Transplantation, Homologous; Immunoglobulin E; Graft versus host disease; Eosinophil cationic protein; Pediatric stem cell transplantation; Atopy; Asthma
• ISSN: 0939-5555; 1432-0584
• DOI: 10.1007/s00277-011-1402-1

Allogeneic hematopoietic stem cell transplantation (HSCT) in childhood is associated with severe pulmonary complications, but the pathophysiologic mechanisms remain unclear. Our aim was to evaluate the association of total and specific IgE, eosinophil cationic protein (ECP) and eosinophilia in HSCT recipients with pulmonary complications. We prospectively measured total and specific serum IgE, eosinophils, and ECP before and 28, 100, and 180 days after HSCT. We included 30 children (age 2–17 years) undergoing HSCT. Nine patients had a history of previous atopy without being associated with pulmonary complications after HSCT until day +360. Specific IgE levels showed a decline after HSCT, associated with the absence of allergy symptoms, suggesting a reduction of atopy. Elevated total serum IgE levels occurred in seven patients on day +28 after HSCT. This elevation did not coincide with allergy symptoms. ECP showed no correlation with total allergy symptoms, eosinophilia, IgE levels, or pulmonary complications. There was a significant correlation (
p
 = 0.0367) between ECP levels on day +28 and concurrent acute graft-versus-host disease (GvHD). Non-atopic serum ECP and IgE levels are elevated on day +28 after HSCT in children, with ECP showing a potential relation to acute GvHD.