Structure‐Activity Relationships in Nucleic‐Acid‐Templated Vectors Based on Peptidic Dynamic Covalent Polymers

The use of nucleic acids as templates, which can trigger the self‐assembly of their own vectors represent an emerging, simple and versatile, approach toward the self‐fabrication of tailored nucleic acids delivery vectors. However, the structure‐activity relationships governing this complex templated...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 29; no. 7; pp. e202202921 - n/a
Main Authors:	Su, Dan‐Dan, Ali, Lamiaa M. A., Coste, Maëva, Laroui, Nabila, Bessin, Yannick, Barboiu, Mihail, Bettache, Nadir, Ulrich, Sébastien
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-02-2023 Wiley-VCH Verlag John Wiley and Sons Inc
Subjects:	Assembly Chemistry Complexation Deoxyribonucleic acid DNA dynamic covalent polymers Fabrication Life Sciences Monomers nucleic acid complexation Nucleic Acids peptides Polymers RNA, Small Interfering - genetics siRNA siRNA delivery Structure-Activity Relationship templated self-assembly siRNA delivery peptides nucleic acid complexation templated self-assembly dynamic covalent polymers Templated self-assembly SiRNA delivery Peptides Nucleic acid complexation Dynamic covalent polymers
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Summary:	The use of nucleic acids as templates, which can trigger the self‐assembly of their own vectors represent an emerging, simple and versatile, approach toward the self‐fabrication of tailored nucleic acids delivery vectors. However, the structure‐activity relationships governing this complex templated self‐assembly process that accompanies the complexation of nucleic acids remains poorly understood. Herein, the class of arginine‐rich dynamic covalent polymers (DCPs) composed of different monomers varying the number and position of arginines were studied. The combinations that lead to nucleic acid complexation, in saline buffer, using different templates, from short siRNA to long DNA, are described. Finally, a successful peptidic DCP featuring six‐arginine repeating unit that promote the safe and effective delivery of siRNA in live cancer cells was identified. Structure–activity Relationships in Nucleic‐Acid‐Templated Vectors Based on Peptidic Dynamic Covalent Polymers (M. Barboiu, N. Bettache, S. Ulrich et al.), @DDSU0407; @M_Cste; @MihailBarboiu; @IBMM_Balard
Bibliography:	These authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.202202921