Antibacterial Activity of a Sulfated Galactan Extracted from the Marine Alga Chaetomorpha aerea Against Staphylococcus aureus

• Published in: Biotechnology and bioprocess engineering Vol. 16; no. 5; pp. 937 - 945
• Main Authors: Pierre, Guillaume, Universite de La Rochelle, UFR Sciences, Batiment Marie Curie, avenue Michel Crepeau, La Rochelle, France, Sopena, Valerie, Universite de La Rochelle, UFR Sciences, Batiment Marie Curie, avenue Michel Crepeau, La Rochelle, France, Juin, Camille, Universite de La Rochelle, UFR Sciences, Batiment Marie Curie, avenue Michel Crepeau, La Rochelle, France, Mastouri, Amira, Universite de La Rochelle, UFR Sciences, Batiment Marie Curie, avenue Michel Crepeau, La Rochelle, France, Graber, Marianne, Universite de La Rochelle, UFR Sciences, Batiment Marie Curie, avenue Michel Crepeau, La Rochelle, France, Maugard, Thierry, Universite de La Rochelle, UFR Sciences, Batiment Marie Curie, avenue Michel Crepeau, La Rochelle, France
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society for Biotechnology and Bioengineering 01-10-2011; Springer Nature B.V; 한국생물공학회
• Subjects: Algae; ALGAS MARINAS; ALGUE MARINE; Antibacterial activity; Antimicrobial activity; Antimicrobial agents; Aquatic plants; Aqueous solutions; Arabinose; Bacteria; Biotechnology; Carbohydrates; CHAETOMORPHA AEREA; Chemistry; Chemistry and Materials Science; Chromatography; Dextran sulfate; Fourier transforms; fucoidan; galactans; Galactose; Glucose; Gram-negative bacteria; Gram-positive bacteria; Industrial and Production Engineering; Investigations; Lactose; Life Sciences; Methanol; Microorganisms; Minimum inhibitory concentration; Molecular weight; Polysaccharides; Proteins; Research Paper; Saccharides; Salmonella; SEAWEEDS; STAPHYLOCOCCUS AUREUS; Staphylococcus infections; Studies; sulfated galactan; 생물공학; France; antibacterial activity; sulfated galactan; seaweed
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-011-0224-2

The in vitro antimicrobial activity of the marine green algae Chaetomorpha aerea was investigated against gram-positive bacteria, gram-negative bacteria, and a fungus. The water-soluble extract of algae was composed of a sulfated (6.3%) galactan with a molecular weight of 1.160 × 10∨6 Da and a global composition close to commercial polysaccharides, such as dextran sulfate or fucoidan. The polysaccharide was composed of 18% arabinose, 24% glucose, and 58% galactose. The re-suspended extracts (methanol, water) exhibited selective antibacterial activities against 3 gram-positive bacteria including Staphylococcus aureus (ATCC 25923). Minimum inhibitory concentration and minimum bactericidal concentration tests showed that the sulfated galactan could be a bactericidal agent for this strain (40 mg/mL). The results of this study confirmed the potential use of the green algae Chaetomorpha aerea as a source of antibacterial compounds.