Differences in prefrontal cortex GABA/glutamate ratio after acute restraint stress in rats are associated with specific behavioral and neurobiological patterns

• Published in: Neuroscience Vol. 285; pp. 155 - 165
• Main Authors: Drouet, J.-B, Fauvelle, F, Maunoir-Regimbal, S, Fidier, N, Maury, R, Peinnequin, A, Denis, J, Buguet, A, Canini, F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 29-01-2015; Elsevier - International Brain Research Organization
• Subjects: Acute Disease; Adenylate Kinase - metabolism; Animals; Corticosterone - blood; Exploratory Behavior - physiology; GABA; gamma-Aminobutyric Acid - metabolism; glucocorticoids; glutamate; Glutamates - metabolism; Life Sciences; locomotion; Male; Motor Activity - physiology; Neurobiology; Neurology; Neurons and Cognition; prefrontal cortex; Prefrontal Cortex - metabolism; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger - metabolism; Stress, Psychological - metabolism; TOR Serine-Threonine Kinases - metabolism; ALAT; prefrontal cortex; locomotion; alanine aminotransferase; 1H-HRMAS-MRS; N-acetylaspartate; LDH; mammalian target of rapamycin; CPMG; GABA transaminase; mTOR; creatine kinase; glucocorticoids; glutamate; glutamate decarboxylases; CK; lactate dehydrogenase; enhanced chemiluminescence; GAD; aspartate aminotransferase; ECL; NAA; HPA; GABA; AMPK; adenosine monophosphate-activated protein kinase; hypothalamo-pituitary–adrenocortical; ASAT; Carr–Purcell–Meiboom–Gill; GABA-T; 1H high-resolution magic angle spinning magnetic resonance spectroscopy
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.10.058

Highlights • After 1 h restraint, the rats increased their prefrontal cortex GABA and glutamate contents. • The stressed rats can be classified according to GABA/glutamate ratio (High G/g vs. Low G/g). • The H-G/g rats presented decreased prefrontal cortex activation and increased HPA axis activation featuring an enhanced stress. • The H-G/g rats had a reduced locomotion speed together with neophobia and sustained exploration behavior in open field. • The prefrontal G/g ratio might underpin the stress-related inter-individual variability.