A Randomized Trial of Enhanced Therapy for Early Syphilis in Patients with and without Human Immunodeficiency Virus Infection

A Randomized Trial of Enhanced Therapy for Early Syphilis in Patients with and without Human Immunodeficiency Virus Infection

Since 1987, several reports have described neurosyphilis and other complications of syphilis in patients infected with the human immunodeficiency virus (HIV), 1 – 7 often after the patients have been treated with penicillin G benzathine, as recommended by the Centers for Disease Control and Preventi...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 337; no. 5; pp. 307 - 314
Main Authors: Rolfs, Robert T, Joesoef, M. Riduan, Hendershot, Edward F, Rompalo, Anne M, Augenbraun, Michael H, Chiu, Michael, Bolan, Gail, Johnson, Steven C, French, Pamela, Steen, Eric, Radolf, Justin D, Larsen, Sandra, Brady, William E, Wagner, Kenneth F, D'Aquilante, Debra A
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 31-07-1997
Subjects:
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
HIV
Human immunodeficiency virus
Infections
Medical sciences
Penicillin
Pharmacology. Drug treatments
Treponema pallidum
United States > US
Philadelphia Pennsylvania
Human
Immunopathology
Spirochaetales
AIDS
Immune deficiency
Treponematosis
Infection
Penicillin derivatives
Antibiotic
Concomitant disease
Chemotherapy
Sexually transmitted disease
Treatment
Viral disease
Syphilis
Amoxicillin
Bacteriosis
Bacteria
Treponemataceae
Antibacterial agent
Benzathine benzylpenicillin
Spirachaetosis
Probenecid
Treponema pallidum
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Description
Summary:Since 1987, several reports have described neurosyphilis and other complications of syphilis in patients infected with the human immunodeficiency virus (HIV), 1 – 7 often after the patients have been treated with penicillin G benzathine, as recommended by the Centers for Disease Control and Prevention (CDC). Also, in 1987 viable treponemes were identified in the cerebrospinal fluid of two HIV-infected patients after this therapy. 8 These observations have prompted questions about the adequacy of the CDC-recommended treatment for HIV-infected patients with early syphilis. 3 , 9 – 11 The efficacy of the recommended therapy for patients with early syphilis who are not infected with HIV was . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199707313370504