Laser processing of polymer constructs from poly(3-hydroxybutyrate)

• Published in: Journal of biomaterials science. Polymer ed. Vol. 26; no. 16; pp. 1210 - 1228
• Main Authors: Volova, T.G., Tarasevich, A.A., Golubev, A.I., Boyandin, A.N., Shumilova, A.A., Nikolaeva, E.D., Shishatskaya, E.I.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02-11-2015
• Subjects: Adhesion; Animals; Biocompatibility; Biomedical materials; biopolymers; Bone Marrow Cells - cytology; Bone Marrow Cells - ultrastructure; Bones; Cell Adhesion; Cell Survival; Cells, Cultured; Cupriavidus necator - metabolism; Elastic Modulus; Fibroblasts; Humans; Hydroxybutyrates - chemistry; Hydroxybutyrates - metabolism; Laser processing; Lasers, Gas; Membranes, Artificial; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - ultrastructure; Mice; NIH 3T3 Cells; Plates; poly(3-hydroxybutyrate); Polyesters - chemistry; Polyesters - metabolism; polymer materials; Polymers - chemistry; Polymers - metabolism; Polymers - radiation effects; Porosity; Rats, Wistar; Stem cells; Surface Properties; Tensile Strength; Three dimensional; Tissue Scaffolds - chemistry; biopolymers; laser processing; biocompatibility; polymer materials; poly(3-hydroxybutyrate)
• ISSN: 0920-5063; 1568-5624
• DOI: 10.1080/09205063.2015.1082810

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laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration.