Description of an oral Chagas disease outbreak in Venezuela, including a vertically transmitted case

We describe the eleventh major outbreak of foodborne Trypanosoma cruzi transmission in urban Venezuela, including evidence for vertical transmission from the index case to her fetus. After confirming fetal death at 24 weeks of gestation, pregnancy interruption was performed. On direct examination of...

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Bibliographic Details
Published in:	Memórias do Instituto Oswaldo Cruz Vol. 112; no. 8; pp. 569 - 571
Main Authors:	Noya, Belkisyolé Alarcón de, Pérez-Chacón, Gladymar, Díaz-Bello, Zoraida, Dickson, Sonia, Muñoz-Calderón, Arturo, Hernández, Carlos, Pérez, Yadira, Mauriello, Luciano, Moronta, Eyleen
Format:	Journal Article
Language:	English
Published:	Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01-08-2017 Fundação Oswaldo Cruz (FIOCRUZ)
Subjects:	Adolescent Adult Chagas disease Chagas Disease - complications Chagas Disease - epidemiology Chagas Disease - transmission Disease Outbreaks Female Fetal Death - etiology Food Parasitology Foodborne Diseases - parasitology Humans Hydrops Fetalis - parasitology Infectious Disease Transmission, Vertical oral transmission outbreaks PARASITOLOGY Polymerase Chain Reaction Pregnancy Short Communication TROPICAL MEDICINE Urban Population Venezuela Venezuela - epidemiology vertical transmission Young Adult Chagas disease vertical transmission Venezuela outbreaks oral transmission
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Summary:	We describe the eleventh major outbreak of foodborne Trypanosoma cruzi transmission in urban Venezuela, including evidence for vertical transmission from the index case to her fetus. After confirming fetal death at 24 weeks of gestation, pregnancy interruption was performed. On direct examination of the amniotic fluid, trypomastigotes were detected. T. cruzi specific-polymerase chain reaction (PCR) also proved positive when examining autopsied fetal organs. Finally, microscopic fetal heart examination revealed amastigote nests. Acute orally transmitted Chagas disease can be life threatening or even fatal for pregnant women and unborn fetuses owing to vertical transmission. There is therefore an urgent need to improve national epidemiologic control measures.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 AUTHORS’ CONTRIBUTION BAN and GP-C - Drafted the manuscript; ZD-B, AM-C and LM - conceived and performed the laboratory tests; BAN, GP-C, CH and YD - carried out the clinical assessment; SD - performed the fetal anatomopathological study and provided the autopsy report and photographs; EM - insisted on the negative contacts and discovered the participation of the third patient; BAN, GPC and ZD - jointly developed the structure and arguments for the paper. All authors read and approved the final manuscript.
ISSN:	0074-0276 1678-8060 1678-8060 0074-0276
DOI:	10.1590/0074-02760170009