A Comparative Study of Antioxidant System and Intensity of Lipid Peroxidation in Type 2 Diabetes Mellitus and Ischemic Stroke Aggravated and Not Aggravated by Type 2 Diabetes Mellitus

• Published in: Bulletin of experimental biology and medicine Vol. 151; no. 5; pp. 564 - 566
• Main Authors: Tsakanova, G. V., Ayvazyan, V. A., Boyajyan, A. S., Arakelova, E. A., Grigoryan, G. S., Guevorkyan, A. A., Mamikonyan, A. A
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-09-2011; Springer; Springer Nature B.V
• Subjects: Aged; Antioxidants; Antioxidants - metabolism; Biomedical and Life Sciences; Biomedicine; Blood; Brain Ischemia - blood; Brain Ischemia - complications; Brain Ischemia - enzymology; Case-Control Studies; Cell Biology; Ceruloplasmin - metabolism; Data processing; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - enzymology; Diabetics; Diet therapy; Female; Humans; Internal Medicine; Ischemia; Laboratory Medicine; Lipid Peroxidation; Lipid Peroxides - blood; Male; Middle Aged; Oxidative Stress; Pathology; Statistics, Nonparametric; Stroke; Stroke (Disease); Stroke patients; Type 2 diabetes; antioxidants; diabetes; ischemic stroke; lipid hydroperoxides
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-011-1383-z

The survey was conducted on patients with type 2 diabetes mellitus and on patients with ischemic stroke aggravated and not aggravated by type 2 diabetes mellitus. A comparative study of the function of antioxidant system and the intensity of oxidative stress induced by lipid peroxidation (LPO) in the blood was carried out. Stroke aggravated by diabetes was characterized by higher intensity of LPO than stroke not aggravated by diabetes, which, apparently, determines the more severe course of stroke in patients with diabetes. The mechanisms of compensatory response to oxidative stress at the level of antioxidants in stroke aggravated by diabetes also differed from those in stroke not aggravated by diabetes. These data indicate the need of using water-soluble low-molecular-weight antioxidants in the treatment of stroke aggravated by diabetes.