A review on chemical-induced inflammatory bowel disease models in rodents

• Published in: The Korean journal of physiology & pharmacology Vol. 18; no. 4; pp. 279 - 288
• Main Authors: Randhawa, Puneet Kaur, Singh, Kavinder, Singh, Nirmal, Jaggi, Amteshwar Singh
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Physiological Society and The Korean Society of Pharmacology 01-08-2014; 대한약리학회
• Subjects: Review; 약리학; Inflammatory bowel disease; Oxazolone; Acetic acid; TNBS; DSS
• ISSN: 1226-4512; 2093-3827
• DOI: 10.4196/kjpp.2014.18.4.279

Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological factors involved in the perpetuation of IBD remain uncertain, development of various animal models provides new insights to unveil the onset and the progression of IBD. Various chemical-induced colitis models are widely used on laboratory scale. Furthermore, these models closely mimic morphological, histopathological and symptomatical features of human IBD. Among the chemical-induced colitis models, trinitrobenzene sulfonic acid (TNBS)-induced colitis, oxazolone induced-colitis and dextran sulphate sodium (DSS)-induced colitis models are most widely used. TNBS elicits Th-1 driven immune response, whereas oxazolone predominantly exhibits immune response of Th-2 phenotype. DSS-induced colitis model also induces changes in Th-1/Th-2 cytokine profile. The present review discusses the methodology and rationale of using various chemical-induced colitis models for evaluating the pathogenesis of IBD.