Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy

• Published in: Biomaterials Vol. 117; pp. 54 - 65
• Main Authors: Chen, Wei-Hai, Luo, Guo-Feng, Qiu, Wen-Xiu, Lei, Qi, Liu, Li-Han, Wang, Shi-Bo, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-02-2017
• Subjects: Advanced Basic Science; Animals; Antineoplastic Agents - administration & dosage; Cercopithecus aethiops; COS Cells; Crystallization - methods; Dentistry; Dual-modal imaging; Female; Humans; Magnetic Resonance Imaging - methods; MCF-7 Cells; Mesoporous silica nanoparticle; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence - methods; Nanocapsules - administration & dosage; Nanocapsules - chemistry; Nanocapsules - ultrastructure; Nanopores - ultrastructure; Neoplasms, Experimental - diagnostic imaging; Neoplasms, Experimental - drug therapy; Photochemotherapy - methods; Photodynamic/chemo therapy; Photosensitizing Agents - administration & dosage; Printing, Three-Dimensional; Silicon Dioxide - chemistry; Supramolecular photosensitizer; Theranostic Nanomedicine - methods; Treatment Outcome; Triazines - administration & dosage; Tumor-target; Mesoporous silica nanoparticle; Tumor-target; Supramolecular photosensitizer; Dual-modal imaging; Photodynamic/chemo therapy
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2016.11.057

Abstract Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd3+ ) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd3+ . The TPZ@MCMSN-Gd3+ could be specifically uptaken by CD44 receptor overexpressed tumor cells and respond to hyaluronidase (HAase) to trigger the release of therapeutics. As confirmed by in vivo studies, TPZ@MCMSN-Gd3+ showed preferential accumulation in tumor site and significantly inhibited the tumor progression by the collaboration of PDT and bioreductive chemotherapy under NIR fluorescence/MR imaging guidance. Taken together, this supraPSs based strategy paves a new paradigm of the way for the construction of theranostic nanoplatform.