Diastolic Carotid Artery Longitudinal Wall Motion Is Sensitive to Both Aging and Coronary Artery Disease Status Independent of Arterial Stiffness

• Published in: Ultrasound in medicine & biology Vol. 43; no. 9; pp. 1906 - 1918
• Main Authors: Au, Jason S, Valentino, Sydney E, McPhee, Patrick G, MacDonald, Maureen J
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01-09-2017
• Subjects: Adult; Age Factors; Aged; Aging; Aging - physiology; Arterial compliance; Arterial structure; Arterial wall motion; Carotid Arteries - diagnostic imaging; Carotid Arteries - physiopathology; Coronary artery disease; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - physiopathology; Diastole; Female; Humans; Male; Radiology; Sensitivity and Specificity; Speckle tracking; Ultrasonography - methods; Ultrasound; Vascular Stiffness - physiology; Young Adult; Arterial compliance; Arterial structure; Aging; Arterial wall motion; Speckle tracking; Ultrasound; Coronary artery disease
• ISSN: 0301-5629; 1879-291X
• DOI: 10.1016/j.ultrasmedbio.2017.04.026

Abstract We investigated the ability of systolic and diastolic carotid artery longitudinal wall motion (CALM) to delineate expected differences in arterial health in individuals representing a range of both age and health status. We recruited 161 younger healthy adults (aged 24 ± 5 y), 51 older healthy adults (aged 70 ± 5 y) and 14 adults with coronary artery disease (aged 67 ± 8 y) for resting assessment of CALM and arterial stiffness. All CALM parameters were reduced in the old healthy adults and adults with coronary artery disease compared with the young healthy adults ( p  < 0.01), with diastolic velocity and maximum diastolic acceleration being further reduced in the adults with coronary artery disease than in the older healthy adults ( p  < 0.01). Diastolic CALM parameters were more strongly related to age (β range: −0.46 to −0.53) than systolic CALM parameters (β range: −0.24 to −0.44). In contrast to previous examinations of a variety of CALM parameters, diastolic CALM may provide superior promise in terms of characterizing arterial wall properties, with additional sensitivity to cardiovascular disease status.