Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer

• Published in: Clinical and translational medicine Vol. 12; no. 3; pp. e749 - n/a
• Main Authors: Zhu, Yinghui, He, Xin, Li, Shu, Gan, Yichao, Li, Zheng, Wang, Hanying, Dong, Haojie, Zhang, Lei, Xue, Sheng‐Li, Xu, Yang, Li, Ling
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-03-2022; John Wiley and Sons Inc; Wiley
• Subjects: Bone marrow; Cancer; Cell cycle; Conflicts of interest; DNA damage; Drug Resistance, Neoplasm - genetics; HMGA1a Protein - metabolism; Humans; Kinases; Letter to Editor; Leukemia; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Phosphorylation; Phosphotransferases; Proteins; Proteomics; Remission (Medicine); Transcription factors
• ISSN: 2001-1326; 2001-1326
• DOI: 10.1002/ctm2.749

CSNK2A1) or CDK family members was higher in F relative to R specimens (Figure 2C; Table S4). [...]DEPMAP analysis revealed that depleting CDK family members in AML cell lines decreased cell viability (a gene with a score < –1 indicates an essential gene) (Figure 2D). [...]CK2 inhibition by CX-4945 significantly enhanced cytarabine-induced cell death in chemo-failure AML cells (Figure 2F). [...]we next focused on CK2 substrates in context of haematopoiesis. [...]when we treated MA9/ITD cells with cytarabine (AraC), S3D cells showed some resistance relative to cells expressing S3A or MOCK (Figure 4E-G).