Preliminary findings for preemptive analgesia with inhaled morphine: Efficacy in septoplasty and septorhinoplasty cases

• Published in: Otolaryngology-head and neck surgery Vol. 135; no. 1; pp. 85 - 89
• Main Authors: Önal, Selami Ateş, Keleş, Erol, Toprak, Gonca Çağlar, Demirel, İsmail, Alpay, H. Cengiz, Avci, Levent
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Mosby, Inc 01-07-2006; SAGE Publications
• Subjects: Administration, Inhalation; Adult; Analgesics, Opioid - administration & dosage; Anesthesia, Inhalation - methods; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Morphine - administration & dosage; Nasal Septum - surgery; Nose Deformities, Acquired - surgery; Prospective Studies; Rhinoplasty - methods; Treatment Outcome
• ISSN: 0194-5998; 1097-6817
• DOI: 10.1016/j.otohns.2006.02.012

The aim of this study was to assess the efficacy of inhaled morphine for preemptive analgesia in patients who undergo septoplasty or septorhinoplasty.
Eighty ASA I-II patients scheduled for septoplasty or septorhinoplasty were recruited and randomly divided into 2 groups that received different treatments 10 minutes prior to induction. The preemptive analgesia group (Group P, n = 40) received 65 μg kg
−1 morphine sulphate (a 3-mL volume) via an oral nebulizer, and the control group (Group C, n = 40) received 3 mL 0.9% sodium chloride (physiological saline) via the same type of nebulizer. Blood pressure, oxygen saturation, heart rate, time to first requirement for analgesia, and occurrence of nausea/vomiting were recorded.
There were no significant differences between Groups P and C with respect to age, body weight, sex distribution, or duration of surgery. There was also no significant difference between the group frequencies of postoperative nausea/vomiting. The time to first requirement for analgesia was significantly longer in Group P than Group C.
The results of this preliminary study suggest that a single dose of inhaled morphine administered preemptively prior to septoplasty or septorhinoplasty provides effective postoperative analgesia.
EBM rating: B-3b