Normalization of pH level and gastric mucosa after eradication of H. pylori in the remnant stomach

• Published in: Journal of gastroenterology and hepatology Vol. 23; no. s2; pp. S258 - S261
• Main Authors: Kato, Shunji, Matsukura, Norio, Matsuda, Noriko, Tsuchiya, Shinichi, Naito, Zenya, Tajiri, Takashi
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01-12-2008; Wiley-Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Biological and medical sciences; Biopsy; chronic atrophic gastritis; Chronic Disease; eradication of H. pylori; Female; Gastrectomy; Gastric Acid - secretion; Gastric Acidity Determination; gastric juice pH level; Gastric Mucosa - drug effects; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Gastric Mucosa - secretion; Gastric Mucosa - surgery; Gastric Stump; Gastritis, Atrophic - metabolism; Gastritis, Atrophic - microbiology; Gastritis, Atrophic - pathology; Gastritis, Atrophic - therapy; Gastroenterology. Liver. Pancreas. Abdomen; Gastroscopy; Helicobacter Infections - metabolism; Helicobacter Infections - microbiology; Helicobacter Infections - pathology; Helicobacter Infections - therapy; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Pepsinogen A - analysis; Pepsinogen C - analysis; remnant stomach; Severity of Illness Index; Stomach Neoplasms - microbiology; Stomach Neoplasms - prevention & control; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Outcome; updated Sydney System; Stomach; Atrophic gastritis; Mucosa; updated Sydney System; Eradication; chronic atrophic gastritis; Gastroenterology; pH; Digestive diseases; eradication of H. pylori; gastric juice pH level; remnant stomach; Gastric juice; Gastric disease
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/j.1440-1746.2008.05447.x

Background:  The Updated Sydney System (USS) is used to evaluate chronic gastritis and chronic atrophic gastritis (CAG) due to H. pylori infection. Here, we investigated USS scores and gastric juice pH levels in H. pylori infection‐positive or ‐eradicated patients with remnant stomach after surgery.
Methods:  Gastric juice pH levels were measured using pH test‐tape in 197 patients (112 H. pylori‐positive and 85 H. pylori‐negative after eradication) who had undergone distal gastrectomy and conventional H. pylori eradication therapy.
Results:  In H. pylori infection‐positive remnant stomach cases, gastric juice pH showed a reverse correlation with pepsinogen I/II ratio, and H. pylori infection‐negative patients following eradication showed associations with the degree of atrophy and intestinal metaplasia at both the anastomosis and in the corpus. Further, pH levels in these patients were normalized time depending after the eradication in the remnant stomach.
Conclusions:  Eradication therapy for the remnant stomach contributes to the possible improvement of stomach conditions by controlling the pH level of gastric juice. This effect will be protective against the risk of secondary stomach carcinogenesis in the remnant stomach.