A new anthracene derivative from marine Streptomyces sp. W007 exhibiting highly and selectively cytotoxic activities

• Published in: Marine drugs Vol. 9; no. 9; pp. 1502 - 1509
• Main Authors: Zhang, Hongyu, Wang, Hongpeng, Cui, Hongli, Li, Zonggang, Xie, Zeping, Pu, Yang, Li, Fuchao, Qin, Song
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-09-2011; Molecular Diversity Preservation International
• Subjects: anthracene; Anthracenes - chemistry; Anthracenes - isolation & purification; Anthracenes - pharmacology; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - pharmacology; Antifungal Agents - pharmacology; Cell Line, Tumor; cytotoxicity; Humans; Magnetic Resonance Spectroscopy; Microbial Viability - drug effects; Streptomyces; Streptomyces - metabolism; structure establishment; Water Microbiology; anthracene; Streptomyces; structure establishment; cytotoxicity
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md9091502

A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.