Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

• Published in: Journal of natural medicines Vol. 62; no. 4; pp. 470 - 472
• Main Authors: Astulla, Adil, Zaima, Kazumasa, Matsuno, Yosuke, Hirasawa, Yusuke, Ekasari, Wiwied, Widyawaruyanti, Aty, Zaini, Noor Cholies, Morita, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01-10-2008
• Subjects: Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Antimalarials - isolation & purification; Antimalarials - pharmacology; Biomedical and Life Sciences; Biomedicine; Complementary & Alternative Medicine; Harmaline - isolation & purification; Harmaline - pharmacology; Harmine - isolation & purification; Harmine - pharmacology; Medicinal Chemistry; Natural Medicine Note; Peganum - chemistry; Pharmacology/Toxicology; Pharmacy; Phenylephrine; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Sciences; Plasmodium falciparum - drug effects; Quinazolines - isolation & purification; Quinazolines - pharmacology; Rats; Seeds; Vasodilation - drug effects; Vasodilator Agents - isolation & purification; Vasodilator Agents - pharmacology; Harmaline; Deoxyvasicinone; Antiplasmodial activity; Vasorelaxant activity; Harmine; Vasicinone
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-008-0259-7

Bioassay-guided purification from the seeds of
Peganum harmala
led to the isolation of harmine (
1
), harmaline (
2
), vasicinone (
3
), and deoxyvasicinone (
4
). Harmine (
1
) and harmaline (
2
) showed a moderate in vitro antiplasmodial activity against
Plasmodium falciparum
. Quinazoline alkaloid, vasicinone (
3
), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.