Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation

Patients with symptomatic, paroxysmal, untreated atrial fibrillation were randomly assigned to antiarrhythmic drug therapy or cryoablation. At 1 year, there was a significantly lower rate of recurrence of atrial fibrillation with cryoablation than with drug therapy.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 384; no. 4; pp. 305 - 315
Main Authors:	Andrade, Jason G, Wells, George A, Deyell, Marc W, Bennett, Matthew, Essebag, Vidal, Champagne, Jean, Roux, Jean-Francois, Yung, Derek, Skanes, Allan, Khaykin, Yaariv, Morillo, Carlos, Jolly, Umjeet, Novak, Paul, Lockwood, Evan, Amit, Guy, Angaran, Paul, Sapp, John, Wardell, Stephan, Lauck, Sandra, Macle, Laurent, Verma, Atul
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 28-01-2021
Subjects:	Ablation Adult Adverse events Aged Anti-Arrhythmia Agents - adverse effects Anti-Arrhythmia Agents - therapeutic use Antiarrhythmics Arrhythmia Atrial Fibrillation - drug therapy Atrial Fibrillation - prevention & control Atrial Fibrillation - surgery Atrial Flutter Balloon treatment Cardiac arrhythmia Catheter Ablation - adverse effects Catheters Cryosurgery Drug dosages Drug therapy Female Fibrillation Heart Heart Rate Humans Kaplan-Meier Estimate Male Middle Aged Monitoring systems Monitoring, Physiologic Patients Proportional Hazards Models Quality of Life Recurrence Secondary Prevention Single-Blind Method Statistical analysis Tachyarrhythmia Tachycardia Canada
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Description
Summary:	Patients with symptomatic, paroxysmal, untreated atrial fibrillation were randomly assigned to antiarrhythmic drug therapy or cryoablation. At 1 year, there was a significantly lower rate of recurrence of atrial fibrillation with cryoablation than with drug therapy.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2029980