Current applications of nanoemulsions in cancer therapeutics

• Published in: Nanomaterials (Basel, Switzerland) Vol. 9; no. 6; p. 821
• Main Authors: Sánchez-López, Elena, Guerra, Mariana, Dias-Ferreira, João, Lopez-Machado, Ana, Ettcheto, Miren, Cano, Amanda, Espina, Marta, Camins, Antoni, Garcia, Maria Luisa, Souto, Eliana B.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 31-05-2019; MDPI AG
• Subjects: Antigens; Cancer; Cancer therapies; Cell migration; Charged particles; Càncer; Drug delivery systems; Drugs; Experimental pharmacology; Farmacologia experimental; Formulations; Hydrophobicity; Hypoxia; Lipids; Metastasis; Multidrug resistance; multifunctional nanoemulsions; Nanoemulsions; Nanoparticles; Nanopartícules; Organs; Permeability; Pharmaceutical sciences; Pharmacy; Prostate; Review; Science & Technology; Sistemes d'alliberament de medicaments; Solubility; targeted delivery; Toxicity; Tumor cells; Tumors; Vascular endothelial growth factor; Portugal; Spain; targeted delivery; cancer; multifunctional nanoemulsions
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano9060821

Nanoemulsions are pharmaceutical formulations composed of particles within a nanometer range. They possess the capacity to encapsulate drugs that are poorly water soluble due to their hydrophobic core nature. Additionally, they are also composed of safe gradient excipients, which makes them a stable and safe option to deliver drugs. Cancer therapy has been an issue for several decades. Drugs developed to treat this disease are not always successful or end up failing, mainly due to low solubility, multidrug resistance (MDR), and unspecific toxicity. Nanoemulsions might be the solution to achieve efficient and safe tumor treatment. These formulations not only solve water-solubility problems but also provide specific targeting to cancer cells and might even be designed to overcome MDR. Nanoemulsions can be modified using ligands of different natures to target components present in tumor cells surface or to escape MDR mechanisms. Multifunctional nanoemulsions are being studied by a wide variety of researchers in different research areas mainly for the treatment of different types of cancer. All of these studies demonstrate that nanoemulsions are efficiently taken by the tumoral cells, reduce tumor growth, eliminate toxicity to healthy cells, and decrease migration of cancer cells to other organs.
This work was supported by the Spanish Ministry of Science and Innovation (SAF-2016-33307). M.L.G., M.E. (Marta Espina), A.C. (Amanda Cano) and E.S.L. belong to 2014SGR-1023. The first author, E.S.L., acknowledges the support of Institute of Nanoscience and Nanotechnology (ART2018 project). The authors want to acknowledge the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE) under the project UID/AGR/04033/2013, M-ERA-NET-0004/2015-PAIRED, co-funded by FEDER, under the partnership Agreement PT2020.