Dose of remifentanil for minimizing the cardiovascular changes to tracheal intubation in pediatric patients

• Published in: Korean journal of anesthesiology Vol. 59; no. 3; pp. 167 - 172
• Main Authors: Yoon, Sang-Ho, Kim, Kyung-Han, Seo, Suk-Hwan
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Anesthesiologists 01-09-2010; Korean Society of Anesthesiologists; 대한마취통증의학회
• Subjects: cardiovascular changes; children; Clinical; remifentanil; tracheal intubation; 마취과학; Children; Cardiovascular changes; Remifentanil; Tracheal intubation
• ISSN: 2005-6419; 2005-7563
• DOI: 10.4097/kjae.2010.59.3.167

The purpose of this study was to investigate a dosage of remifentanil for attenuating cardiovascular changes during anesthetic induction in pediatric anesthesia.
We examined the effect of remifentanil on the cardiovascular responses to intubation in 90 children ASA 1 patients, aged 4-15 years, randomly allocated to receive 1.0 ug/kg remifentanil as a bolus (R 1), or 1.5 ug/kg remifentanil (R 1.5), or 2.0 ug/kg remifentanil (R 2). Before induction, IV midazolam 0.05 mg/kg was given for sedation. After glycoppylorate 5 ug/kg, thiopental 4.0 mg/kg was injected within 10 seconds and followed by remifentanil. Following check the unconsciousness, patients were received rocuronium 0.6 mg/kg and tracheal intubation were performed 90s later, and anesthesia was maintained with 2% sevoflurane in air/oxygen. Systolic arterial pressure (SAP), mean arterial pressure (MAP) and heart rate (HR) were measured at before induction of anesthesia (B), before, just after and at 1, and 3 minutes after tracheal intubation.
SAP and HR were increased than B values in the three groups just after intubation (P < 0.05). The percentage increases of SAP and HR were 30% and 30% of B values, respectively, in R 1; 19% and 24% in R 1.5; 10% and 22% in R 2. There were significant differences between R 2 group and other two groups in SAP and HR (P < 0.05).
In pediatric anesthesia, a bolus injection of 2 ug/kg remifentanil (R 2) was a dosage to attenuate the cardiovascular responses after intubation in pediatric patients.