Randomized Trial of Platelet-Transfusion Thresholds in Neonates

• Published in: The New England journal of medicine Vol. 380; no. 3; pp. 242 - 251
• Main Authors: Curley, Anna, Stanworth, Simon J, Willoughby, Karen, Fustolo-Gunnink, Susanna F, Venkatesh, Vidheya, Hudson, Cara, Deary, Alison, Hodge, Renate, Hopkins, Valerie, Lopez Santamaria, Beatriz, Mora, Ana, Llewelyn, Charlotte, D’Amore, Angela, Khan, Rizwan, Onland, Wes, Lopriore, Enrico, Fijnvandraat, Karin, New, Helen, Clarke, Paul, Watts, Timothy
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 17-01-2019
• Subjects: Age; Birth weight; Bleeding; Blood platelets; Death; Evidence-based medicine; Female; Gestational age; Health services; Hemorrhage; Hemorrhage - etiology; Hemorrhage - prevention & control; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - mortality; Infant, Premature, Diseases - therapy; Infants; Male; Medical research; Neonates; Newborn babies; Platelet Count; Platelet Transfusion; Platelets; Premature birth; R&D; Research & development; Thrombocytopenia; Thrombocytopenia - complications; Thrombocytopenia - mortality; Thrombocytopenia - therapy; United Kingdom > UK; Ireland
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1807320

The rate of death or major bleeding was significantly higher among preterm infants with severe thrombocytopenia assigned to transfusions at higher platelet-count thresholds (50,000 per cubic millimeter) than among those assigned to lower thresholds (25,000 per cubic millimeter).