Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease

• Published in: Saudi journal of kidney diseases and transplantation Vol. 32; no. 6; pp. 1628 - 1636
• Main Authors: Sheerah, Areej, Al-Ahmed, Rafif, El-Desoky, Sherif, Alhasan, Khalid, Albanna, Amr, Shalaby, Mohamed, Kari, Jameela
• Format: Journal Article
• Language: English
• Published: Riyadh Wolters Kluwer India Pvt. Ltd 01-11-2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Bones; Children's furniture; Chronic kidney failure; Cinacalcet; Density; Kidney diseases; Parathyroid hormone
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.352423

Advanced chronic kidney disease with mineral and bone disorder have a significant obstacles to control serum bone profile [serum intact parathyroid hormone (iPTH), calcium and phosphorus] which subsequently have major effect on optimal bone strength, final adult height, and cardiovascular health. A retrospective, observational study, including a total of 36 children with end-stage kidney disease (ESKD). Fourteen children who were prescribed cinacalcet had been compared with the remaining 22 children who were managed with standard care. We report the efficacy and safety of cinacalcet for treatment of refractory secondary hyperparathyroidism (SHPT) in children with ESKD. After 6 months of cinacalcet treatment, the mean level of iPTH serum level decreased by 56% from 202 pmol/L [95% confidence interval (CI): 150-253] to 88 pmol/L (95% CI: 41-136), compared to the change observed in the control group (P <0.001). None of our patients reported serious adverse effects or developed hypocalcemia. Cinacalcet could be an effective and safe alternative to treat severe SHPT in children with ESKD. Further long-term and large-scale studies are necessary to confirm its safety and efficacy.