Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study

• Published in: PloS one Vol. 19; no. 11; p. e0312385
• Main Authors: Fukuda, Kensuke, Mizukami, Kazuhiro, Yamaguch, Daisuke, Tanaka, Yuichiro, Hashiguchi, Kazutoshi, Akutagawa, Takashi, Shimoda, Ryo, Suzuki, Sho, Miike, Tadashi, Sumida, Yorinobu, Maeda, Hidehito, Sasaki, Fumisato, Gushima, Ryosuke, Miyamoto, Hideaki, Hashiguchi, Keiichi, Yamaguchi, Naoyuki, Ohira, Tetsuya, Kinjo, Tetsu, Ohnita, Ken, Moriyama, Tomohiko, Ohtsu, Kensei, Aso, Akira, Ogawa, Ryo, Ueo, Tetsuya, Fukuda, Masahide
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 05-11-2024; Public Library of Science (PLoS)
• Subjects: Atrophy; Biology and Life Sciences; Cancer; Care and treatment; Color; Diagnosis; Diagnostic imaging; Endoscopy; Gastric cancer; Infections; Intestine; Lesions; Medical imaging; Medicine and Health Sciences; Metaplasia; Methods; Multivariate analysis; Oncology, Experimental; Patient education; Patients; Physical Sciences; Poor visibility; Research and Analysis Methods; Stomach cancer; Visibility; White light; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0312385

This study investigated clinicopathological factors associated with the visibility of early gastric cancer and the efficacy of linked color imaging. Ninety-seven lesions were analyzed, with good visibility in 49 and poor visibility in 48. Multivariate analysis revealed small lesion size (odds ratio 1.89) and presence of endoscopic intestinal metaplasia (odds ratio 0.49) as significantly associated with the poor visibility of early gastric cancer. Mean visibility score was significantly higher for linked color imaging (P<0.001). Mean score for linked color imaging was significantly higher in the poor visibility group (P<0.001), but not significantly different in the good visibility group (P = 0.292). Mean score was significantly higher with linked color imaging in cases with endoscopic intestinal metaplasia (P = 0.0496) and lesions <20 mm in diameter (<10 mm, P = 0.002; 10-20 mm, P = 0.004). Lesion size and endoscopic intestinal metaplasia are associated with the visibility of early gastric cancer in white light imaging. Linked color imaging improves visibility of gastric cancer with these factors.