Immune modulation after traumatic brain injury

Immune modulation after traumatic brain injury

Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The subsequent response, evolved to limit an overwhelming systemic inflammatory response and to induce healing, involves the autonomic nervous syste...

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Bibliographic Details
Published in:Frontiers in medicine Vol. 9; p. 995044
Main Authors: Bouras, Marwan, Asehnoune, Karim, Roquilly, Antoine
Format: Journal Article
Language:English
Published: Switzerland Frontiers media 01-12-2022
Frontiers Media S.A
Subjects:
immunomodulatory therapy
immunosuppression
inflammation
innate immunity
Life Sciences
Medicine
traumatic brain injury
traumatic brain injury
immunosuppression
innate immunity
immunomodulatory therapy
inflammation
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Summary:Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The subsequent response, evolved to limit an overwhelming systemic inflammatory response and to induce healing, involves the autonomic nervous system, hormonal systems, and the regulation of immune cells. This physiological response induces an immunosuppression and tolerance state that promotes to the occurrence of secondary infections. This review describes the immunological consequences of TBI and highlights potential novel therapeutic approaches using immune modulation to restore homeostasis between the nervous system and innate immunity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
PMCID: PMC9751027
Edited by: Anthony John Rostron, Newcastle University, United Kingdom
This article was submitted to Intensive Care Medicine and Anesthesiology, a section of the journal Frontiers in Medicine
Reviewed by: Alasdair Jubb, University of Cambridge, United Kingdom; Selvakumar Govindhasamy Pushpavathi, The University of Iowa, United States
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2022.995044