Chronic myeloid leukemia: Relevance of cytogenetic and molecular assays

Highlights • Ph negative and variant Ph rearrangements are diagnosed with cytogenetic tests. • Additional abnormalities in Ph+/−karyotype are revealed by conventional cytogenetic. • Conventional and molecular cytogenetic are the standard tests for diagnosis of CML. • Quantitative PCR is the standard...

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Bibliographic Details
Published in:	Critical reviews in oncology/hematology Vol. 97; pp. 263 - 274
Main Authors:	Bennour, Ayda, Saad, Ali, Sennana, Halima
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ireland Ltd 01-01-2016
Subjects:	Chronic myeloid leukemia Clonal evolution Cytogenetic Analysis Cytogenetics FISH Hematology, Oncology and Palliative Medicine Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Philadelphia chromosome Tyrosine kinase inhibitors Variant rearrangement Clonal evolution Cytogenetics FISH Chronic myeloid leukemia Tyrosine kinase inhibitors Philadelphia chromosome Variant rearrangement
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Summary:	Highlights • Ph negative and variant Ph rearrangements are diagnosed with cytogenetic tests. • Additional abnormalities in Ph+/−karyotype are revealed by conventional cytogenetic. • Conventional and molecular cytogenetic are the standard tests for diagnosis of CML. • Quantitative PCR is the standard test for molecular monitoring of CML. • The cytogenetic and molecular responses are the gold standards of CML therapy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1040-8428 1879-0461
DOI:	10.1016/j.critrevonc.2015.08.020