Quercetin Regulates Lipid Metabolism and Fat Accumulation by Regulating Inflammatory Responses and Glycometabolism Pathways: A Review

• Published in: Nutrients Vol. 16; no. 8; p. 1102
• Main Authors: Wang, Yaodong, Li, Zezheng, He, Jianhua, Zhao, Yurong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-04-2024; MDPI
• Subjects: Adipocytes; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Animals; Anti-Inflammatory Agents - pharmacology; Antioxidants; Bioavailability; Bioflavonoids; Body mass index; Carbohydrates; Cytokines; Enzymes; Fatty acids; Flavones; Flavonoids; Glucose; glycometabolism; Humans; Inflammation; Inflammation - metabolism; Insulin; Insulin Resistance; Investigations; Kinases; lipid metabolism; Lipid Metabolism - drug effects; Lipids; Mediation; Metabolism; Metabolites; Obesity; Obesity - drug therapy; Obesity - metabolism; Overweight; Physiological aspects; Polyphenols; Proteins; quercetin; Quercetin - pharmacology; Review; Signal Transduction - drug effects; Small intestine; Tumor necrosis factor-TNF; Type 2 diabetes; quercetin; inflammation; obesity; lipid metabolism; glycometabolism
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16081102

Fat synthesis and lipolysis are natural processes in growth and have a close association with health. Fat provides energy, maintains physiological function, and so on, and thus plays a significant role in the body. However, excessive/abnormal fat accumulation leads to obesity and lipid metabolism disorder, which can have a detrimental impact on growth and even harm one's health. Aside from genetic effects, there are a range of factors related to obesity, such as excessive nutrient intake, inflammation, glycometabolism disease, and so on. These factors could serve as potential targets for anti-obesity therapy. Quercetin is a flavonol that has received a lot of attention recently because of its role in anti-obesity. It was thought to have the ability to regulate lipid metabolism and have a positive effect on anti-obesity, but the processes are still unknown. Recent studies have shown the role of quercetin in lipid metabolism might be related to its effects on inflammatory responses and glycometabolism. The references were chosen for this review with no date restrictions applied based on the topics they addressed, and the databases PubMed and Web of Sicence was used to conduct the references research, using the following search terms: "quercetin", "obesity", "inflammation", "glycometabolism", "insulin sensitivity", etc. This review summarizes the potential mechanisms of quercetin in alleviating lipid metabolism through anti-inflammatory and hypoglycemic signaling pathways, and describes the possible signaling pathways in the interaction of inflammation and glycometabolism, with the goal of providing references for future research and application of quercetin in the regulation of lipid metabolism.