New therapies for rheumatoid arthritis

• Published in: Clinical and experimental immunology Vol. 140; no. 2; pp. 195 - 204
• Main Authors: Goldblatt, F., Isenberg, D. A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-05-2005; Oxford University Press; Blackwell Science Inc
• Subjects: Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - immunology; Humans; Immunologic Factors - therapeutic use; Receptors, Interleukin-1 - antagonists & inhibitors; Receptors, Interleukin-6 - antagonists & inhibitors; Reviews; rheumatoid arthritis; treatment; Tumor Necrosis Factor-alpha - antagonists & inhibitors
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1111/j.1365-2249.2005.02744.x

Summary
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease, which continues to cause significant morbidity in affected persons. In the past few years, a number of new exciting therapeutic options have become available. These reflect the application of knowledge obtained from advancements in understanding of disease pathogenesis and underlying molecular mechanisms. A number of these therapies are outlined in the following review, including the various biological modifiers, in particular, anti‐tumour necrosis factor‐α agents and interleukin‐1 (IL‐1) receptor antagonists, which have been developed in recognition of the role of pro‐inflammatory cytokines in RA. Also notable, is the current interest centring on the development and trials with B cell depletion therapies, specifically rituximab, in patients with RA. This demonstrates acknowledgment for a more significant role for B cells in the aetiology of RA, in contrast to the long held view that RA was a predominantly T cell mediated disease. To evaluate this therapeutic option for RA, salient features from recent rituximab trials have been collated. Finally, a selection of other therapeutic alternatives, including anti‐IL‐6 receptor monoclonal antibody and tacrolimus, and newer anti‐rheumatic therapies presently in development are summarized.