The p53 knowledgebase: an integrated information resource for p53 research

• Published in: Oncogene Vol. 26; no. 11; pp. 1517 - 1521
• Main Authors: LIM, Y. P, LIM, T. T, CHAN, Y. L, SONG, A. C. M, YEO, B. H, VOJTESEK, B, COOMBER, D, RAJAGOPAL, G, LANE, D
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 08-03-2007; Nature Publishing Group
• Subjects: Amino acid sequence; Apoptosis; Biological and medical sciences; Cancer; Cell cycle; Cell death; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Computational biology; DNA damage; Expert systems; Fundamental and applied biological sciences. Psychology; Genes, p53; Genetic aspects; Genomics; Health aspects; Humans; Medical research; Molecular and cellular biology; Mutation; Oncology; p53 Protein; Post-translation; Protein interaction; Proteins; Senescence; Signal transduction; Transcription factors; Tumor suppressor genes; Tumors; Singapore; TP53 Gene; web portal; Database; Information; Carcinogenesis; Tumor suppressor gene; p53
• ISSN: 0950-9232; 1476-5594
• DOI: 10.1038/sj.onc.1209952

The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in one of several ways, that is, cell cycle arrest, senescence or programmed cell death (apoptosis). Mutations in the tumor suppressor gene tp53, which affects the key transcriptional regulatory processes in cell growth and death, occur frequently in cancer and helps explain why p53 has been called the guardian of the genome. There is a vast body of published knowledge on all aspects of p53's role in cancer. To facilitate research, it would be helpful if this information could be collected, curated and updated in a format that is easily accessible to the user community. To this end, we initiated the p53 knowledgebase project (http://p53.bii.a-star.edu.sg). The p53 knowledgebase is a user-friendly web portal incorporating visualization and analysis tools that integrates information from the published literature with other manually curated information to facilitate knowledge discovery. This includes curated information on sequence, structural, mutation, polymorphisms, protein-protein interactions, transcription factors, transcriptional targets, antibodies and post-translational modifications that involve p53. The goal is to collect and maintain all relevant data on p53 and present it in an easily accessible format that will be useful to researchers in the field.